Dengue
BACKGROUND

Dengue study group is established in 1997 focusing on dengue virus (DENV) research and other flaviviruses. This group is operated under the leadership of Prof.Soegeng Soegijanto. Dengue illness is mosquito born disease which has been widespread becoming endemic in Indonesia. Our group aims to gain understanding of dengue illness in molecular level and to develop novel approach to suppress DENV infection. Having many experiences and supported by advanced technology, our group excels in DENV identification and characterization. In addition, to study the DENV vectors, we have been working together with entomology study group.


RESEARCH ACTIVITIES/EXPERIENCES
Several research projects are carried out by dengue study group.
Epidemiology of Dengue

This project focuses on mapping the spread of dengue case in Indonesia. To conduct this particular research dengue study group has been collaborating with many health institutions sxh as hospital and clinics (Puskesmas) all over Indonesia. This search is also part of collaboration projects with Kobe ,university, Japan, which belongs to CRC-ERID programs.

Dengue Antiviral

Apart from epidemiology in CRC-ERID programs we have been also working on research to develop dengue antiviral. In this project we work together with NPMRD study group since this antiviral are plant-based molecules.

Identification of Flaviviruses

Beside dengue as the main focus, this group has worked on identification of other flaviviruses such as west nile, japanese e-cephalitis, yellow fever, and zika virus. During the recently zika outbreak which happened in Brazil and several countries, dengue study group working together with Airlangga hospital has done screening to identify whether zika has come in to Indonesia.

Monitoring System

Dengue study group have recently established a project in making real time monitoring application as a mean of control system to prevent dengue outbreak and as information source of dengue as well as dengue-related issues. This ongoing study is collaboration with IT department of ITD.

Other Activities

In order to share and disseminate our knowledge and understanding to society we regularly held events such as seminar, workshop, and socialization. In addition, we also provide several services including DENV Serotyping, DENV Sequencing, and Identification of other flaviviruses.

OUTPUT

From the projects mentioned several journal articles have been published:

  1. Siti Churrotin et al (2016). Dengue virus type 1 isolated in Indonesia shows a close phylogenetic relationship with the strains that caused the autochthonous dengue outbreak in japan in 2014. Japanese journal of Infectious Diseases. DOI: 10.7883/yoken.JJID.2015.516.
  2. Tomohiro Kotaki et al (2016). Divergence of the dengue virus type 2 cosmopolitan genotype associated with two predominant serotype shifts between 1 and 2 in Surabaya, Indonesia, 2008-2014. Infection, Genetics and Evolution. 37. 88-93. D01:10.10164meegid.2015.11.002.
  3. Teguh Had Sucipto et al (2016). Immunofluorescence assay method to detect dengue virus in Paniai-Papua. AIP Conference Proceedings. 1718. D01:10.1063/1.4943313.
  4. Atsushi Yamanaka et al (2016). Dengue virus infection-enhancing antibody activities against Indonesian strains in inhabitants of central Thailand. Microbes and Infection. 18.227-284.
  5. Soegeng Soegijanto et al (2015). An appropriate diagnosis of dengue virus infection in some cases who had and were being treated in soerya hospital sepanjang-indonesia. Indonesian Journal of Tropical and Infectious Disease. Vol.5.No.6.
  6. Arif Nur Muhammad Ansori et al (2015). Differences of universal and multiplex primer for detection of dengue virus from patients suspected dengue hemorrhagic fever (DHF) in Surabaya. Indonesian Journal of Tropical and Infectious Disease. VoI.5.No.6.
  7. Tamaki Okabayashi (2014). Detection of Cikungunya virus antigen by a novel rapid immunochromatographic test. Journal of Clinical Microbiology. D01:10.1128/1CM.02033-14