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(ITD-UNAIR) On February 10, 2023, the Institute of Tropical Disease Universitas Airlangga received a visit from Lecturers and Education Personnel from the Faculty of Public Health, Hasanuddin University. The purpose of this visit is to benchmark to the laboratories located at ITD. This visit was welcomed by Laura Navika Yamani, S.Si., M.Si., PhD. as the head of human resources of ITD. After remarks and discussions related to the development of research at ITD, the visit continued to 5 laboratories in ITD, namely, the Malaria Laboratory, Entomology Laboratory, Human Genetic Laboratory, Dengue Laboratory, and Gastroenteritis Laboratory. In this visit they were welcomed by researchers in each laboratory, they explained the field they were engaged in and the development of research developed in each laboratory (Sucipto, TH. 2023)

Thursday, January 26 2023, ITD Universitas Airlangga was visited by the CDC USA. at this event, started by remarks and opening remarks from the Chancellor of Airlangga University, Prof. Dr. Moh. Nasih, SE., MT., Ak and also the Vice Chancellor for Research, Communication, Community Development Prof. Dr. Dra. Ni Nyoman Tri Puspaningsih. M.Sc. Furthermore, a presentation was made by showing the ITD video profile and also presenting research activities and developments by the chairman of the institution, Prof. Maria Inge Lucida, Ph.D.,. In his presentation, the USA CDC attracted interest in information related to developments in ITD related to the world of research in the health sector. From this, interesting discussions emerged such as the methods used, the tools, the sources and the results of their development. In the discussion, additional information was also provided from the Vice Chancellor for International & Information Digitization Prof. dr. Muhammad Mifthahussurur. M.Kes., Sp.PD-KGEH., Ph.D., FIINASIM because he is also one of the senior researchers at ITD in the field of H. Pylori. After the discussion was carried out a joint visit to the Avian Infleunza Lab in the Whole Sample Genome test section, they were happy to discuss the use of the method and its practice during the presentation from ITD researchers. full of hope, cooperation can be increased which in the future can affect the quality of research and development of science in the field of health to foreign countries.

The Institute of Tropical Disease received visits from representatives of the Japanese Consulate General and Kanzai Medical University. The representative from the Consul General is Mr. Ishii Yutaka as Deputy Consul General of Japan Surabaya and Prof. Toshimasa Nishiyama, MD & DMSc as professor and chairman of Kanzai Medical University. They were welcomed by the chairman Prof. Maria Inge Lusida, Ph.D., Deputy ITD Prof. Fedik Abdul Rantam, Prof. Soetjipto, Prof. Kazufumi Shimizu, Prof. Sri Subekti and representative researchers from the Dengue, Entomology and Avian Influenza laboratories. In this meeting, an introduction was made to each institution starting from Kanzai Medical University which was continued by ITD UNAIR presentations. In this case, Prof. Toshimasa Nishiyama, MD & DMSc explained what things are owned and all the activities that exist at Kanzai Medical University, he also explained that they would be open to giving students the opportunity to take part in a 4-year doctoral scholarship program there. Not only that, he also explained about the research and collaboration that had been carried out by Kanzai Medical University. From this explanation, parties from ITD UNAIR were very interested in considering and deciding on future collaboration. The hope is that ITD UNAIR can collaborate with more foreign parties to be able to develop the world of research, especially in the world of health for all foreign countries in the future.

January 19, 2023, the Tropical Disease Institute received a visit from the Airlangga University Faculty of Medicine student organization (CIMSA). This visit consisted of foreign students from the Faculdade Ciências Médicas de Minas Gerais Brazil and the Faculty of Medicine, Airlangga University, this visit saw activities in several laboratories such as Human Genetics, Avian Influenza, Natural Products (NPMRD), and gastroenterology. it is hoped that this visit will be able to share information related to activities, collaboration, and research that is being developed at the Institute for Tropical Diseases which can later become an attraction for foreign researchers so that collaboration can be created later.

Universitas Airlangga held an archive exhibition of Covid-19 pandemic at Surabaya Alun-Alun Youth Center on Tuesday, January 3, 2023. The exhibition presents archives of policy documents, photos and videos that describe UNAIR’s efforts to deal with the Covid-19 pandemic, facilities and innovations made during the pandemic. UNAIR Secretary Dr Koko Srimulyo Drs MSi said that the Covid-19 pandemic archive exhibition aims to store documentation of Covid-19 handling in Indonesia. So that future generations can study and deal with similar outbreaks better. Koko also hopes that there will be a Covid-19 museum in Indonesia to collect and store better documentation of Covid-19 in Indonesia. He said that the Covid-19 archive exhibition was a trigger for UNAIR to build a museum about Covid. “Because in Indonesia there is no museum about Covid. Perhaps the idea of ​​a museum about Covid is the first in Indonesia. The Indonesian government should build a museum about Covid-19 like this,” he said. Meanwhile, UNAIR Vice Rector for Research, Innovation, and Community Development, Prof Dr Ni Nyoman Tri Puspaningsih MSi said that in the exhibition showcased three kinds of archives: Covid-19 handling at the forefront, treatment of infected people, and the handling of the deceased as a result of Covid-19. “So I think that all archiving activities are complete, from the beginning to the end, from those who have recovered to those who cannot be saved. And awards, photos, and videos,” she said. Prof Nyoman also explained that UNAIR had sent 1,225,000 doses of Inavac vaccine to the Ministry of Health, which were ready for use for adults. However, they are still waiting for BPOM examination. “Now every batch of vaccine products is checked by BPOM, even though they have received an EUA (Emergency Use Authorization) it does not mean they are distributed immediately. But it is checked again so that unwanted residue does not occur, if it is safe, it is distributed,” she said. Prof Nyoman added that the Inavac vaccine was ready to be distributed to 34 provinces. She hopes that East Java will get some of the vaccine doses. (*) Author: Muhammad Mu’afa Rahman Editor: Binti Q. Masruroh Source : news.unair.ac.id

Monday 8 August 2022, the Institute of Tropical Disease, Universitas Airlangga received a visit from the Student Executive Board (BEM) of the Faculty of Pharmacy, Universitas Airlangga and a student exchange from Egypt. This visit was welcomed by the Head of Research Board of the Institute of Tropical Disease (ITD) Universitas Airlangga Marcellino Rudyanto, Drs., Apt., Msi., Ph.D., as well as a lecturer from the Faculty of Pharmacy, Universitas Airlangga. In this activity, the students also visited several laboratories at ITD, including the Dengue Laboratory and the NPMRD Laboratory. Hopefully, this visit can spread information about developing research at ITD abroad.

Friday, August 5, 2022, RC-GERID and the Institute of Tropical Disease held a Workshop with the theme “BSL3- Skill Update”. This workshop is conducted in Hybrid so that participants can listen offline and online. This event was welcomed by the head of ITD Prof. MARIA LUCIA INGE LUSIDA dr., M.Kes., Ph.D., SpMK, moderated by Dengue Laboratory researcher Siti Churrotin S.Si and speaker from Prof. Masanori Kameoka, Ph.D. from Kobe University, Japan. This workshop illustrates how the science of Bio-Safety Laboratory Level develops in terms of spatial planning, usage, and completing tasks according to established standards. It is hoped that the participants will be able to follow the development of science for safety in the implementation, both for diagnosis and research.

{:en}Institute of Tropical Disease (ITD), Universitas Airlangga (UNAIR) hold annual workshop the 6th Molecular and Cell Culture (MCC) at the beginning of July 2022. This event was organized to facilitate transfer knowledge with regard to molecular biology lab techniques to the practitioners, researchers, and academics. This workshop which was scheduled for two days, 5 and 6 July 2022, was opened by ITD-UNAIR director Prof. Maria Inge Lusida, dr., M.Kes., Ph.D. There were a total of 19 participants from various institution and background coming from different regions such as Malang, Surabaya, Semarang, Jakarta, Lombok, and Pontianak. With the theme of “Gene Analysis using Sanger DNA Sequencing” which was explained in theory and hands on practice, participants were expected to understand more easily about the given techniques. In theoretical session, the lecture was delivered by Laura Navika Yamani, Ph.D, The Lecturer of FKM-UNAIR and also researcher in one of the research groups in ITD-UNAIR. The second lecture was presented by Audi Putra Santosa, BSc, The specialist product from PT. Biotek Prima  Indoplus (PT. BPI). During practical period in laboratories, participants were divided into 5 groups and each group was guided by 2 instructors. Participants got opportunities to do hands on experiment starting from DNA extraction, PCR, gel electrophoresis, and sequencing. Besides those activities, participants were also mentored on how to do data analysis from the sequencing result. This bioinformatic activity was guided by Laura Navika Yamani, Ph.D and Mochammad Amin, S.Si.,M.Si (The researcher of ITD_UNAIR). In this workshop, there was also discussion session, in which participants could share their experiences and obstacle from this workshop as well as from their own projects in the home institution. This event was supported by PT. BPI and PUI-PT Research Center on Global Emerging and Re-emerging Infectious Disease (RC-GERID). In this workshop, there was also held a mini exhibition. The exhibition was followed by all research groups in ITD-UNAIR, showing their research by means of publications or top products. Apart from research groups, there was stan from Indonesian Journal of Tropical and Infectious Disease (IJTID) which is an international journal own by ITD-UNAIR. PT. BPI also contributed in this exhibition by displaying some labs equipments (including real time PCR and plate reader), reagents, and consumable materials regarding molecular biology. Besides theory and practice, there was a lab tour program. In this session, participants could directly interact with researchers in each research group of ITD-UNAIR concerning the post and ongoing project. From this, participants could get information with regard to collaboration that can be done in ITD-UNAIR. This workshop was finished by giving certificate and closed by the chief of MCC committee, Ilham Harlan Amarullah, BASc.{:}{:id}Lembaga Penyakit Tropis (LPT), Universitas Airlangga (UNAIR) menyelenggarakan annual workshop ”the 6th Molecular and Cell Culture (MCC)” pada awal bulan Juli 2022. Acara workshop ini diselenggarakan dengan tujuan sebagai sarana transfer knowledge terkait teknik laboratorium biologi molekuler kepada para praktisi, peneliti dan akademisi. Acara yang dilaksanakan selama 2 hari ini yaitu tanggal 5 dan 6 Juli 2022, dibuka langsung oleh ketua LPT-UNAIR Prof. Maria Inge Lusida, dr., M.Kes., Ph.D. Total peserta yang berpartisipasi dalam workshop ini sebanyak 19 orang dari berbagai institusi dan disiplin ilmu yang berasal dari bererapa wilayah diantaranya Malang, Surabaya, Semarang, Jakarta, Lombok, dan Pontianak. Mengusung tema “Gene Analysis using Sanger DNA Sequencing” yang disampaikan secara teori dan praktik secara hands on, para peserta diharapkan mampu memahami dengan mudah tentang teknik yang disampaikan. Pada sesi teori, materi disampaikan oleh Laura Navika Yamani, Ph.D, beliau merupakan dosen FKM-Unair dan juga peneliti di salah satu kelompok studi di LPT-UNAIR. Materi kedua disampaikan oleh Audi Putra Santosa, BSc, beliau merupakan specialist product dari PT. Biotek Prima  Indoplus (PT. BPI). Selama kegiatan praktik di laboratorium, peserta dibagi menjadi 5 kelompok dan masing-masing kelompok didampingi oleh 2 instruktur. Para peserta mendapatkan kesempatan untuk melakukan uji secara hands on mulai dari proses ekstraksi DNA, PCR, elektroforesis gel agarosa, dan sekuensing. Selain penyampaian materi (teori) dan kegiatan praktik di laboratorium, para peserta juga dibimbing bagaimana cara untuk menganalisis hasil sekuensing. Analisis data (hasil sekuensing) secara bioinformatik ini dipandu oleh Laura Navika Yamani, Ph.D dan Mochammad Amin, S.Si.,M.Si (peneliti dari LPT-UNAIR). Pada workshop ini juga ada sesi diskusi, dimana pada sesi ini para peserta bisa berbagi pengalaman dan kendala yang didapatkan selama melakukan kegiatan workshop ini atau kendala yang didapatkan dari institusi asal. Workshop ini didukung oleh PT. BPI dan PUI-PT Research Center on Global Emerging and Re-emerging Infectious Disease (RC-GERID). Pada workshop ini, kami juga menggelar pameran mini. Pameran ini diikuti oleh semua kelompok studi yang terdapat di LPT-UNAIR, yang menampilkan hasil riset baik dalam bentuk publikasi maupun produk unggulan mereka. Selain dari kelompok studi,  juga terdapat stan dari tim Indonesian Journal of Tropical and Infectious Disease (IJTID) yang merupakan jurnal internasional yang dimiliki oleh LPT-UNAIR. PT. BPI juga turut serta dalam pameran ini dengan menampilkan beberapa alat laboratorium, reagent, dan bahan habis pakai yang terkait bidang biologi molecular seperti mesin real time PCR dan plate reader. Selain teori dan praktik, ada juga program tour laboratorium. Dengan program ini para peserta bisa berinteraksi langsung dengan para peneliti dimasing-masing laboratorium LPT-UNAIR terkait informasi project/riset yang sedang dan telah para peneliti LPT-UNAIR kerjakan. Dari informasi ini para peserta bisa mendapatkan informasi kerjsama penelitian yang bisa dikerjakan di LPT-UNAIR. Workshop diakhiri dengan pembagian sertifikat dan ditutup oleh Ketua Acara workshop The 6th MCC, Ilham Harlan Amarullah, BASc.{:}

{:en}Monday, July 4, 2022, at Aston Inn Batu Malang, East Java, an FGD (forum group discussion) and workshop on the preparation of scientific articles were held by C-NPMRD (Center-Natural Product Medicine Research and Development), ITD (Institute of Tropical Disease), Universitas Airlangga. The event lasted for three days intending to provide and stimulate C-NPMRD researchers to be able to finalize their research results as scientific articles which can be published internationally. The FGD and workshop activities on the first day were opened by the chairman of NPMRD, Prof. Dr. apt. Aty Widyawaruyanti, M.Si,. with explanation of the vision and mission of C-NPMRD and the role of C-NPMRD in the scientific community. The vision of C-NPMRD is to become a leading and innovative center in the field of research and development of natural medicine at the national and international. Meanwhile, the missions of C-NPMRD are to conduct research and development through national and international collaborations, publications, drug discovery research to increase capacity building for Indonesian drug independence and to develop excellent human resources. In the event, the C-NPMRD researchers were divided into 4 discussion groups, namely the Phytochemical team, the Malaria team, the Hepatitis C Viral (HCV) and other viral teams, and the Amoeba team. The four teams explained research progress, scientific publications, research services, and further research plans. On the first day, that was also mapped which research was eligible to be written as scientific articles. On the second and third days, the researchers wrote scientific articles together and discussed them according to their research expertise. A total of two publications submitted followed by 8 publications will be submitted until August 2022. This achievement and spirit of togetherness are expected to contribute directly to C-NPMRD and ITD Universitas Airlangga therefore can contribute to accelerating Universitas Airlangga as a World Class University by a target rank of 401-500 on the Times Higher Education (THE) Asia University Ranking system through international publications and citations index. (lyd-DT){:}{:id}Senin, 4 Juli 2022, bertempat di Aston Inn Batu Malang, Jawa Timur telah diselenggarakan acara FGD (forum grub discussion) dan workshop penyusunan artikel ilmiah oleh C-NPMRD (Center-Natural Product Medicine Research and Development), LPT (Lembaga Penyakit Tropis), Universitas Airlangga. Acara tersebut berlangsung selama tiga hari dengan tujuan memberikan stimulus kepada para peneliti C-NPMRD untuk dapat memfinalisasi hasil penelitian mereka dalam bentuk artikel ilmiah sehingga dapat dipublikasikan secara internasional. Kegiatan FGD dan workshop dihari pertama dibuka oleh ketua NPMRD, Prof. Dr. apt. Aty Widyawaruyanti, M.Si,. dengan paparan visi dan misi C-NPMRD serta peran NPMRD dalam masyarakat ilmiah. Adapun visi C-NPMRD yaitu menjadi center yang unggul dan inovatif dalam bidang penelitian dan pengembangan obat bahan alam di tingkat nasional dan internasional. Sedangkan misi dari C-NPMRD sendiri adalah melakukan riset dan pengembangan melalui kolaborasi nasional maupun internasional, publikasi dan riset drug discovery untuk peningkatan capacity building kemandirian obat Indonesia, serta pengembangan SDM unggul. Dalam FGD tersebut para peneliti C-NPMRD dibagi dalam 4 kelompok grup diskusi yaitu tim Fitokimia, tim Malaria, tim Hepatitis C Viral (HCV) and other viral, dan tim Amoeba. Keempat tim tersebut melakukan paparan progress penelitian, publikasi ilmiah, pelayana penelitian, serta rencana penelitian lanjutan. Pada hari pertama ini juga dipetakan penelitian-penelitian mana yang sudah layak untuk ditulis dalam bentuk artikel ilmiah. Adapun pada hari kedua dan ketiga, para peneliti melakukan penulisan artikel ilmiah bersama dan berdiskusi sesuai bidang kepakaran masing-masing. Total publikasi yang disubmitt sejumlah dua buah dengan 8 publikasi akan menyusul sampai bulan Agustus 2022. Capaian dan semangat kebersamaan ini diharapkan akan berkontribusi secara langsung pada C-NPMRD dan LPT Univeristas Airlangga sehingga mempercepat Universitas Airlangga sebagai World Class University dengan target rank 401-500 pada sistem peringkatan Times Higher Education (THE) Asia Universitas Ranking melalui publikasi internasional dan sitasi index. (lyd-DT){:}

The Coronavirus Disease (COVID-19), caused by the novel coronavirus was detected in December 2019 in Wuhan, China for the first time and quickly spread into a global pandemic. This study aims to predict the potential of macroalgae bioactive compounds as SARS-CoV-2 antivirals by inhibiting the ACE2 receptor through an in silico approach. Twenty-seven macroalgal compounds were obtained from PubChem (NCBI, USA), while the target protein ACE2 receptor was collected from the Protein Data Bank (PDB). Then the drug similarity screening was carried out using Lipinski’s rules from five web servers and prediction of bioactive compounds was carried out using PASS (predicted activity spectrum for biologically active substances) via an online web server. After the compound was approved by Lipinski’s five rule and PASS online prediction web server, blind docking simulations were performed with PyRx 0.8 software to show the binding energy values. Molecular interaction analysis was performed with BIOVIA Discovery Studio 2016 v16.1.0 and PyMOL v2.4.1 software. There are six macroalgae compounds approved by Lipinski rules and PASS Analysis Online. The result was that the macroalgae siphonaxanthin among 27 macroalgae compounds showed a strong binding energy to bind to the ACE2 receptor with a value of -8.8 kcal/mol. This study also used SARS-CoV-2 drugs as positive controls, namely remdesivir, molnupiravir, baricitinib, lopinavir, oseltamivir, and favipiravir. The results showed that siphonaxanthin had the lowest binding energy compared to common drugs SARS-CoV-2. Macroalgae compounds are predicted to have potential as SARS-CoV-2 antivirals. Thus, further studies need to be investigated with in vitro and in vivo analyzes to confirm the inhibitory activity of siphonaxanthin against SARS-CoV-2. Authors: Teguh Hari Sucipto, Hasriaton Padmi, Rahadian Zainul et al. Article Title: Macroalgae Bioactive Compounds for the Potential Antiviral of SARS-CoV-2: An In Silico Study Detailed information about this scientific article can be found at: https://microbiologyjournal.org/macroalgae-bioactive-compounds-for-the-potential-antiviral-of-sars-cov-2-an-in-silico-study/ Source : unair.ac.id