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{:en}Tuberculosis (TB) and Corona Virus Disease (COVID-19) are infectious diseases that infect the respiratory tract. Tuberculosis is caused by Mycobacterium tuberculosis while COVID-19 is caused by SARS CoV-2. Transmission of the disease is through coughing, sneezing and close contact with infected individuals. Tuberculosis disease has spread throughout the world and it is reported that Indonesia is ranked second in the world (543,874 cases), so, serious attention is needed by various sectors to suppress the transmission and elimination of this disease. During the COVID-19 pandemic during the last two years there were indications of COVID-19 coinfection in pulmonary tuberculosis patients, this was due to the risk and severity caused by COVID-19 disease and the high risk of death due to the development of new diseases in TB patients. Data released by the Ministry of Health of the Republic of Indonesia related to the development of TB cases shows a fluctuating trend over the past decade. In 2020, the incidence of TB cases in Indonesia increased to 845,000 with a mortality of more than 98,000 people. Furthermore, in 2021 there was a decline in cases reaching 2.04% from the previous year as many as 393,323 cases as a result of the government’s attention being focused on reducing the incidence of COVID-19. However, WHO determined that Indonesia urgently needed to carry out epidemiological surveillance of TB disease during the COVID-19 pandemic, this was due to a decrease in monthly and quarterly TB notifications and the first half of 2021 substantially decreased from 2019 in most countries with the highest TB burden. . Reportedly, a relative reduction in annual notifications between 2019 and 2020 was seen in Gabon (80%), the Philippines (37%), Lesotho (35%), Indonesia (31%) and India (25%) so that the real number of TB cases is estimated much higher than those found and treated and a decline in 2021 presumably many cases go unreported. Taking into account the updated information released by the World Health Organization, secondary data-based epidemiological surveillance was carried out by utilizing regional data reports released annually. The data used is the number of confirmed cases of positive TB and COVID-19 in the East Java Province and compared with each other with other factors or determinants. Geographical mapping of the distribution of cases of tuberculosis and COVID-19 was also carried out using the Quantum Geographic Information System (QGIS) to identify areas that have the potential to have the highest level of risk and severity of these two diseases. There are several indicators that are reviewed for the correlation between these two diseases, including: the correlation between the incidence and mortality rates of tuberculosis and COVID-19 cases, the relationship between case cure rates and death rates for tuberculosis cases, the incidence and success rates of tuberculosis treatment, the correlation between treatment success rates. and the death rate of tuberculosis cases, the rate of case recovery, and the death rate of COVID-19 cases as well as the calculation of geographical factors including the ratio of puskesmas, the number of doctors, nurses, midwives, public health workers, environmental health workers, nutritionists, and pharmacists and all ratios are calculated per 100,000 inhabitants. The results of the study obtained that the incidence of tuberculosis in East Java Province in 2020 was 95.49/100,000 population with varying case cure rates. TB cases are dominated by the male sex community. The number of women in East Java in 2020 reached 20,374,104, while men reached 20,291,592. The population with tuberculosis which is dominated by women is only found in Probolinggo district with a higher number of women (604) than men (561). Furthermore, the highest infection rate was found in Madiun (296.51/100,000 population), while the lowest was in Malang (0.07/100,000 population). The incidence ratio of tuberculosis cases based on gender was found for men (117.66/100,000 people) higher than women (93.49/100,000 people). The district with the highest incidence of tuberculosis in males is Madiun (342.62/100,000 population) and the lowest is Pacitan (57.88/100,000 population). Furthermore, in the female gender, the highest incidence of tuberculosis was in Pasuruan (223.16/100,000 people) and the lowest was in Pacitan (93.49/100,000 people). Based on the findings, the highest incidence of COVID-19 infection was found in Mojokerto (789.9/100,000 population), while the lowest was found in Sampang (52.5/100,000 population). Analysis by gender found that the incidence of COVID-19 in women (210.74/100,000 population) was higher than that of men (198.04/100,000 population). Meanwhile, the regency with the highest male population is in Mojokerto (744.46/100,000 people), while the lowest is in Sampang (48.58/100,000 people). The district with the highest incidence of COVID-19 in women is Mojokerto (804.51/100,000 people), while the lowest is in Madiun (51.14/100,000 people). The overall death rate for tuberculosis cases in East Java Province in Indonesia is 3.6%. The highest TB infection CFR was found in Probolinggo (7%), while the lowest was found in Surabaya (0.4%). Meanwhile, the highest CFR of COVID-19 infection was found in Pasuruan (11%), while the lowest was found in Tulungagung 2.1%. Furthermore, the highest cure rate for tuberculosis cases was in Magetan (96.6%), while the lowest was in Batu City (11.3%). Meanwhile, the COVID-19 Case Recovery Rate is defined as a COVID-19 patient with a positive result at the beginning of the RT-PCR, and a negative result at the end of the examination. The highest cure rate for COVID-19 cases was in Sidoarjo (92.6%), while the lowest was found in Tuban (64.5%). The highest success rate of tuberculosis treatment was in Magetan (95.97%), while the lowest was found in Bondowoso (65.89%). Calculation of the number of COVID-19 cases based on age group obtained the highest age in the range of 46-59 years (23,947 individuals), while the lowest was found in the age of 3-6 years (771 individuals). In this study, it was reported that there was no significant relationship between the incidence and mortality of tuberculosis cases (p = 0.912, p>0.05). It was also found that there was no significant relationship between the incidence and case fatality rates for COVID-19 (p = 0.219, p > 0.05), case cure rates and case fatality rates

{:en}On 14-17 June 2022 Airlangga Disease Prevention and Research Center – One Health Collaborating Center (ADPRC-OHCC) in collaboration with the Biosafety Engagement Program (BEP) and Tropical Disease Institute, Universitas Airlangga held a Workshop on Laboratory Biosafety and Biosecurity. This activity aims to improve the understanding and ability of lab workers in applying the principles of biosafety and biosecurity in the laboratory. This workshop was held virtually and face to face at the Tropical Disease Institute, Universitas Airlangga. A total of 25 participants consisting of lab workers at universities, government and hospitals were invited to this activity. The practicum sessions carried out included: risk assessments, hand washing, donning-doffing PPE BSL-2 and spills. Writer : Firdausy Kurnia (ADPRC-OHCC) {:}{:id}Pada tanggal 14-17 Juni 2022 Airlangga Disease Prevention and Research Center – One Health Collaborating Center (ADPRC-OHCC) bekerjasama dengan Biosafety Engagement Program (BEP) dan Lembaga Penyakit Tropis, Universitas Airlangga menyelenggarakan Workshop Biosafety dan Biosecurity Laboratorium. Kegiatan ini bertujuan untuk meningkatkan pemahaman dan kemampuan pekerja lab dalam penerapan prinsip-prinsip biosafety dan biosecurity di laboratorium. Workshop ini dilaksanakan secara virtual dan tatap muka di Tropical Disease Institute Universitas Airlangga. Sebanyak 25 peserta yang terdiri dari pekerja lab di universitas, pemerintah dan rumah sakit diundang dalam kegiatan ini. Penulis : Firdausy Kurnia (ADPRC-OHCC){:}

{:en} Thursday, June 16, 2022, representatives from the Faculty of Health Sciences, Surabaya Muhammadyah University , visited and trained at the Human Genetics Laboratory of the Tropical Disease Institute. The first meeting was welcomed by one of the leaders of the Human Genetics Laboratory, Dr. Agung Sosiawan drg., M.Kes. also provided basic knowledge, then participants did basic practice in the Human Genetics laboratory with the research team. Hopefully, the training and knowledge presented can be useful and useful in developing health sciences. {:}{:id}Kamis, 16 Juni 2022, Perwakilan dari Fakultas Ilmu Kesehatan Universitas Muhammadyah Surabaya melakukan kunjungan dan pelatihan di laboratorium Human Genetik Lembaga Penyakit Tropis. Pertemuan pertama disambut oleh Salah satu pimpinan Laboratorium Human Genetik yaitu Dr. Agung Sosiawan drg., M.Kes. sekaligus memberikan ilmu dasar, selanjutnya peserta melakukan praktik dasar di laboratorium Human Genetik dengan para tim peneliti. Penuh harap, pelatihan dan ilmu yang disajikan bisa bermanfaat dan berguna dalam mengembangkan ilmu kesehatan.{:}

Friday, June 10, 2022, Institute of Tropical Diseases (ITD) Universitas Airlangga received a visit from representatives from PT TEKAD MANDIRI CITRA. This visit was welcomed and attended by ITD leaders, namely the Secretary of ITD, Prof. Dr. FEDIK ABDUL RANTAM drh., as well as representatives of ITD. This meeting discussed the development of the world of research in the world of health as well as supporting the research itself. After the discussion, they visited several laboratories owned by ITD. We hope that this visit will lead to better cooperation and better relations

{:en} Tuesday, May 31, 2022, Institute for Tropical Diseases (ITD) Universitas Airlangga received a visit from representatives from the Ministry of National Development Planning of the Republic of Indonesia/National Development Planning Agency (BAPPENAS). This visit was welcomed and attended by ITD leaders, namely Prof. MARIA LUCIA INGE LUSIDA dr., M.Kes., Ph.D., SpMK , Secretary of ITD, Prof. Dr. FEDIK ABDUL RANTAM drh., as well as representatives of the ITD laboratory. This meeting discussed the development of the health industry, research developments and other issues to advance the world of health. After the discussion, they visited several laboratories owned by ITD. We hope that this visit will lead to better cooperation and better relations {:}{:id}Selasa, 31 Mei 2022, Lembaga Penyakit Tropis (ITD) Universitas Airlangga mendapatkan kunjungan perwakilan dari Kementerian Perencanaan Pembangunan Nasional Republik Indonesia/Badan Perencanaan Pembangunan Nasional (BAPPENAS), Kunjungan ini disambut baik dan dihadiri oleh para pimpinan ITD yaitu Ketua Prof. MARIA LUCIA INGE LUSIDA dr., M.Kes., Ph.D., SpMK , Sekretaris ITD, Prof. Dr. FEDIK ABDUL RANTAM drh., serta perwakilan laboratorium ITD. Pertemuan ini membahas perkembangan industri kesehatan, perkembangan penelitian dan perihal untuk memajukan dunia kesehatan lainnya. Setelah diskusi, mereka melakukan kunjungan ke beberapa laboratorium yang dimiliki ITD. Penuh harap kunjungan ini bisa melahirkan kerja sama dan juga hubungan yang lebih baik{:}

{:en}Coronavirus 2 (SARS‑CoV‑2) is a virus that causes COVID-19 and infects the respiratory organs in humans. The virus was first identified in China in 2019 and later spread to other countries around the world. This study aims to identify the bioactive compound of mangosteen (Garcinia mangostana L.) as an antiviral agent through a dual inhibitory mechanism against SARS-CoV-2 protease through an in silico approach. In this study, the three-dimensional structure of various mangosteen bioactive compounds from the database was examined. Furthermore, all bioactive compounds were analyzed as drugs, prediction of antiviral activity, virtual screening, molecular interactions, and visualization of three-dimensional structures. This aims to determine the potential for bioactive compounds from mangosteen that can function as antiviral agents against SARS-CoV-2. The results indicate that the bioactive compounds from mangosteen have a prospective to provide antiviral agents through multiple inhibitory mechanisms. In summary, the binding of various bioactive compounds from mangosteen results in low binding energy and has the ability to induce protein target binding activity. Bioactive compounds from mangosteen, such as: -mangostin, -mangostin, and -mangostin have low binding energy to the targeted proteins, namely Mpro and PLpro. This is expected to have the ability to induce the activity of these proteins. Furthermore, the bioactive compound has shown the ability to be developed as an antiviral drug described by Lipinski’s rule which consists of a molecular mass <500 Daltons, LogP <5, hydrogen binding donor <5, hydrogen binding donor <10, and a molar bias between 40-130. and prediction of antiviral activity. Therefore, it allows the various bioactive compounds of mangosteen to act as a dual inhibitory mechanism for COVID-19 infection. Authors: Teguh Hari Sucipto, Arif Nur Muhammad Ansori, Rahadian Zainul et al. Article Title: Bioactive Compounds from Mangosteen (Garcinia mangostana L.) as an Antiviral Agent via Dual Inhibitor Mechanism against SARSCoV-2: An In Silico Approach Detailed information about this scientific article can be found at: https://www.phcogj.com/article/1740 Source : news.unair.ac.id Picture Source: Bola.com{:}{:id}Coronavirus 2 (SARS‑CoV‑2) adalah virus yang menyebabkan COVID-19 dan menginfeksi organ pernapasan pada manusia. Virus ini pertama kali diidentifikasi di China pada 2019 dan kemudian menyebar ke negara-negara lain di seluruh dunia. Penelitian ini bertujuan untuk mengidentifikasi senyawa bioaktif dari manggis (Garcinia mangostana L.) sebagai agen antivirus melalui mekanisme inhibitor ganda terhadap SARS-CoV-2 protease melalui pendekatan in silico. Pada penelitian ini struktur tiga dimensi berbagai bioaktif senyawa manggis dari database diperiksa. Selanjutnya, semua senyawa bioaktif dianalisis sebagai obat, prediksi aktivitas antivirus, skrining virtual, interaksi molekuler, dan visualisasi struktur tiga dimensi. Hal ini bertujuan untuk mengetahui potensi senyawa bioaktif dari manggis yang dapat berfungsi sebagai agen antivirus untuk melawan SARS-CoV-2. Hasil menunjukkan bahwa senyawa bioaktif dari manggis memiliki prospektif untuk menyediakan agen antivirus melalui mekanisme penghambatan ganda. Singkatnya, pengikatan berbagai senyawa bioaktif dari manggis menghasilkan energi ikat yang rendah dan memiliki kemampuan untuk menginduksi aktivitas pengikatan target protein. Senyawa bioaktif dari manggis, seperti: α-mangostin, β-mangostin, dan γ-mangostin memiliki energi ikat yang rendah terhadap protein yang ditargetkan yaitu Mpro dan PLpro. Hal ini diharapkan memiliki kemampuan untuk menginduksi aktivitas protein tersebut. Selanjutnya, senyawa bioaktif tersebut telah menunjukkan kemampuan untuk dikembangkan sebagai obat antivirus yang digambarkan oleh aturan Lipinski’s yaitu terdiri dari molekul massa <500 Dalton, LogP <5, donor pengikat hidrogen <5, hidrogen mengikat donor <10, dan bias molar antara 40-130 dan prediksi aktivitas antivirus. Oleh karena itu, memungkinkan berbagai senyawa bioaktif dari manggis untuk bertindak sebagai mekanisme penghambatan ganda untuk infeksi COVID-19. Penulis: Teguh Hari Sucipto, Arif Nur Muhammad Ansori, Rahadian Zainul dkk. Judul Artikel: Bioactive Compounds from Mangosteen (Garcinia mangostana L.) as an Antiviral Agent via Dual Inhibitor Mechanism against SARSCoV-2: An In Silico Approach Informasi detail tentang artikel ilmiah ini dapat dilihat di: https://www.phcogj.com/article/1740 Sumber : news.unair.ac.id Sumber Gambar: Bola.com{:}

{:en} Friday, February 4-6 2022, the Institute of Tropical Disease (ITD) Universitas Airlangga conducted a performance evaluation in Yogyakarta. This is done to seek performance improvements in order to achieve the same goals, including bonding all staff, both administration and researchers as well as leaders, so that good cooperation is formed. While there, the activities were the presentation of performance progress, achievements, evaluations and so on, then outbound training was carried out to improve good cooperation. {:}{:id}Jumat, 4-6 Februari 2022, Institute of Tropical Disease (ITD) Universitas Airlangga melakukan evaluasi kinerja di jogjakarta. Hal ini dilakukan untuk mengupayakan adanya perbaikan kinerja agar bisa mencapai dengan tujuan yang sama termasuk perekatan seluruh staff baik administrasi dan peneliti serta pimpinan agar terbentuk kerja sama yang baik. Selama disana kegiatannya adalah pemaparan progres kinerja, capaian, evaluasi dan sebagainya selanjutnya dilakukan pelatihan outbound untuk meningkatkan kerja sama yang baik.{:}

{:en} Friday, February 4, 2022, the Institute of Tropical Disease (ITD) Universitas Airlangga received a visit from the TNI Commander Andika Perkasa and his team. They visited to find out what the ITD Team was doing, after that they saw several existing laboratories, then discussed the scope of what the ITD team was doing. {:}{:id}Jumat, 4 Februari 2022, Lembaga Penyakit Tropis Universitas Airlangga menerima kunjungan Panglima TNI Andika Perkasa beserta timnya. Mereka berkunjung untuk mengetahui apa yang dilakukan oleh Tim ITD, setelah itu melihat beberapa laboratorium yang ada, kemudian mendiskusikan ruang lingkup yang dilakukan oleh tim ITD.{:}

{:en} Wednesday, January 26, 2022, the Institute Of Tropical disease received a visit from Mr. Thierry Goubier, Mrs. Sandra Vivier, and Mrs. Indri Novitas Sari, who is a representative from the French embassy, ​​came to see the whole genome sample laboratory and communicated with the Covid-19 research team. Hopefully they can find out about the process and developments in the Covid-19 research at ITD so that it can be used as a provision for future collaboration. {:}{:id}Rabu, 26 Januari 2022, Institute Of Tropical disease mendapatkan kunjungan dari Mr. Thierry Goubier, Mrs. Sandra Vivier, dan Mrs. Indri Novitas Sari yang merupakan perwakilan dari keduataan besar prancis, mereka datang untuk melihat laboratorium whole sampel genome dan berkomunikasi dengan tim peneliti Covid-19. Penuh harap mereka bisa mengetahui proses dan perkembangan dalam penelitian covid-19 yang ada di ITD sehingga bisa dijadikan bekal untuk kerja sama nantinya.{:}

{:en}The captioned apprenticeship programme[1] was convened Jointly by JICA and Institute of Tropical Disease – Universitas Airlangga. The programme aims to provide learning opportunity on practical aspects of biorisk management in BSL-3 laboratories. Seven professionals of ITD-UNAIR instructed two apprentices from the central laboratory of Badan POM. Biorisk management is a system or framework that describes the use of practices, operations and training, safety equipment and buildings specifically designed to protect workers, the community and the environment from accidental exposure or unauthorized access, loss, theft, misuse, diversion or intentional release of infectious agents and toxins. The programme covered various topics such as the construction and design, layout and maintenance of BSL-3 laboratory, Standard Operating Procedures (SOPs) for the BSL 3 laboratory, practices relating to procedures for entering and leaving the BSL 3 laboratory, procedures for laboratory work, application of basic principles of biosafety/biosecurity, the overall flow of sample handling and other routine laboratory work applicable to BSL 3. Prof. dr. Maria Inge Lusida, Mkes., PhD, SpMK(K)., Director of Institute of Tropical Disease UNAIR emphasized the benefit of this programme for both ITD and Badan POM. Badan POM is working on the construction of Biosafety Level 3 laboratory and this practical training will be very useful to carry out research and testing in safe condition. The program also provided an opportunity for Badan POM and ITD-UNAIR to continue their communication and establish a relationship that will mutually enhance the technical capacities of both institutions in biorisk management in future. UNAIR has a long history of collaboration with JICA and many Japanese researchers in the field of research and studies on infectious diseases using the BSL 3 laboratory, which was built by JICA/JST SATREPS (2010 -2014) and has been operated and managed for many years with KOBE University and others. ITD-UNAIR’s BSL-3 laboratory is often a place of learning due to the limited presence of BSL-3 in Indonesia Source : https://www.jica.go.jp/{:}{:id}Program magang dengan judul[1] diselenggarakan Bersama oleh JICA dan Institute of Tropical Disease – Universitas Airlangga. Program ini bertujuan untuk memberikan kesempatan belajar tentang aspek praktis manajemen biorisiko di laboratorium BSL-3. Tujuh tenaga profesional ITD-UNAIR menginstruksikan dua orang magang dari laboratorium pusat Badan POM. Manajemen biorisiko adalah sistem atau kerangka kerja yang menggambarkan penggunaan praktik, operasi dan pelatihan, peralatan keselamatan dan bangunan yang dirancang khusus untuk melindungi pekerja, masyarakat dan lingkungan dari paparan yang tidak disengaja atau akses yang tidak sah, kehilangan, pencurian, penyalahgunaan, pengalihan atau pelepasan yang disengaja. dari agen infeksius dan toksin. Program tersebut mencakup berbagai topik seperti konstruksi dan desain, tata letak dan pemeliharaan laboratorium BSL-3, Prosedur Operasi Standar (SOP) laboratorium BSL 3, praktik terkait tata cara masuk dan keluar laboratorium BSL 3, prosedur kerja laboratorium , penerapan prinsip-prinsip dasar biosafety/biosecurity, alur penanganan sampel secara keseluruhan dan pekerjaan laboratorium rutin lainnya yang berlaku untuk BSL 3. Prof dr. Maria Inge Lusida, Mkes., PhD, SpMK(K)., Direktur Institute of Tropical Disease UNAIR menekankan manfaat program ini baik bagi ITD maupun Badan POM. Badan POM sedang mengerjakan pembangunan laboratorium Biosafety Level 3 dan pelatihan praktis ini akan sangat berguna untuk melakukan penelitian dan pengujian dalam kondisi aman. Program ini juga memberikan kesempatan bagi Badan POM dan ITD-UNAIR untuk melanjutkan komunikasi dan menjalin hubungan yang akan saling meningkatkan kapasitas teknis kedua institusi dalam pengelolaan biorisiko di masa mendatang. UNAIR memiliki sejarah panjang kerjasama dengan JICA dan banyak peneliti Jepang di bidang penelitian dan studi penyakit menular menggunakan laboratorium BSL 3 yang dibangun oleh JICA/JST SATREPS (2010 -2014) dan telah dioperasikan dan dikelola selama bertahun-tahun. tahun dengan KOBE University dan lain-lain. Laboratorium BSL-3 ITD-UNAIR sering menjadi tempat belajar karena keterbatasan keberadaan BSL-3 di Indonesia   Sumber : https://www.jica.go.jp/{:}