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Research - Phytochemistry Division

Phytochemistry

Phytochemistry Division

NPMRD is an Universitas Airlangga research center that focused on research about drug discovery and medicine development from natural resources. It was developed to support the research collaboration between Universitas Airlangga, Indonesia, and Kobe University, Japan, granted by JICA/JST SATREPS (2010-2014). In the effort to find a medicine, c-NPMRD combines the best science and technology in pharmacy, chemistry, biology, and medical fields, supported by reliable equipment and staff.
Achievement
• Isolation and identification of several flavonoids as antimalarial compounds from Artocarpus champeden stembark. The results were showed prenylated flavonoids compounds tend to have high antimalarial activity. One of the isolated compounds, Heteroflavone C (IC50 1 nmol/L) showed more potent inhibitory activity against Plasmodium falciparum compare to a well-known antimalarial drug, chloroquine (IC50 6.3 nmol/L).
• Isolation and identification of geranylated flavonoid compounds as antimalarial from Artocarpus altilis leaves.
• Isolation and identification of alkaloid and benzopyran compounds which showed potential activities as anti-Hepatitis C Virus (anti-HCV) from Melicope latifolia leaves and fruits.
• Isolation and identification of Chalepin and Pseudane IX as potential anti-HCV compounds from Ruta Angustifolia leaves
• Isolation and identification of cage xanthone compounds as a promising anti-amebic compounds from Cratoxylum sumatranum stembark.

Ongoing Research
• Bioassay guided isolation of antimalarial compounds from Garcinia parvifolia leaves.
• Isolation and identification more compounds from Artocarpus altilis leaves as active antimalarial compounds.
• Bioassay guided isolation of antimalarial compounds from Artocarpus sericicarpus leaves and stembark.
• Bioassay guided isolation of antimalarial compounds from Cratoxylum sumatranum stembark.

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